Compound guide · 8 min read
MOTS-C: A Complete Research Guide
MOTS-C is a mitochondrial-derived peptide encoded within mtDNA, studied for metabolic regulation and mitochondrial biogenesis. Full guide here.
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a 16 amino acid peptide encoded within the mitochondrial 12S rRNA gene. It is one of a small number of identified mitochondrial-derived peptides currently studied for systemic metabolic effects.
Mechanism of action
Current research indicates MOTS-C may influence AMPK signalling and metabolic homeostasis. It is studied in research models for its potential role in glucose handling, mitochondrial biogenesis and exercise-related adaptation.
Place in the longevity stack
MOTS-C frequently sits alongside GHK-Cu, NAD precursors and SS-31 in laboratory longevity research, each compound covering different mitochondrial or cellular pathways.
Storage
Store lyophilised MOTS-C at minus 20 degrees Celsius long term. Reconstitute with sterile bacteriostatic water and refrigerate at 2 to 8 degrees Celsius. Use within 28 days.
Pair every reconstitution with sterile bacteriostatic water for laboratory-grade results.
Buying MOTS-C UK
Pondok Peptides supplies MOTS-C UK as research-grade lyophilised material with batch-specific COAs and HPLC verified purity.
Products mentioned in this guide
Frequently Asked Questions
Is MOTS-C a mitochondrial peptide?+
Yes. MOTS-C is encoded within mitochondrial DNA and is one of the studied mitochondrial-derived peptides.
What is the purity of Pondok MOTS-C?+
98 percent or higher, HPLC verified, with batch COA on the product page.
Can MOTS-C be combined with NAD?+
Yes. Researchers frequently study them in parallel within the longevity peptide stack.
How should MOTS-C be stored?+
Lyophilised at minus 20 degrees Celsius. Reconstituted at 2 to 8 degrees Celsius for up to 28 days.